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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

Fig. 4

Cp 43 reduced tau phosphorylation in primary cortical neurons. a, c Lysates were prepared from 7 DIV (a) or 17 DIV(c) neurons treated with or without Cp 43 for 72 h as indicated and immunoblotted with antibodies to detect tau-pS262/S356 (12E8), tau-pS202/T205/S208 (AT8), total tau or BIII Tubulin. b, d Quantitative analysis of the effects of increasing Cp 43 concentration on the levels of phosphorylated tau, 12E8 and AT8 epitopes, in 7 DIV (b) and 17 DIV neurons (d). The data are normalised to total tau and the bars represent the average ratio ± SEM (n = 7). *p < 0.05, one-way ANOVA followed by multiple comparison with the Holm-Sidak method

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