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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

Fig. 1

TAOK-pS181 associated with tau pathology in AD and FTLD-tau brain. a Formalin-fixed sections from the entorhinal cortex of AD (Braak stages II, IV and VI), FTLD-tau or control brains were immunostained with antibody to detect phosphorylated and active TAOKs (TAOK-pS181). Strong positive antibody immunoreactivity was observed on NFTs in AD brain sections from early and late disease stages and in FTLD brain sections (arrows indicate magnified NFTs). b AD (Braak VI) or control (CTR) entorhinal cortex brain samples were extracted with sarkosyl and low speed supernatants (LSS) or sarkosyl-soluble (SS) or sarkosyl-insoluble (SI, insoluble tau) fractions immunoblotted with antibodies to detect TAOK1, TAOK2, TAOK-pS181 and GAPDH or tau-pS262/S356 (12E8), tau-pS202/T205/S208 (AT8), total tau and GAPDH. Representative images and immunoblots are shown. Scale bar = 20 μm

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