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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Fig. 7

D409H GBA1 expression shows early induction of ER chaperone grp78 in the A53T α-synuclein transgenic mice. a, Accumulation of grp78, an indicator of ER stress, was analyzed via immunostaining with grp78 and TH antibodies in the SNpc of indicated genotypes at 6 months of age. The scale bar is 50 μm. b, The fluorescence levels of grp78 were analyzed using Image J and compared to non-Tg (n = 3). c and d, Accumulation of grp78 was analyzed via Western blot analysis with grp78 antibody in the ventral midbrain of the indicated genotypes. The grp78 levels were measured using ImageJ

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