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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Fig. 4

D409H GBA1 expression promotes reduction of dopaminergic fiber densities and motor deficit in the striatum of hA53T α-synuclein transgenic mice. a, The striatal TH-immunopositive fiber density was assessed in the striatum of the indicated genotypes at 6 months of age (n = 6 per each group). The scale bar is 250 μm. b, The optical densities of TH positive signals were quantified. c and d, Rotarod and Pole test were assessed at 6 months of age with the indicated genotypes (n = 7 per each group). e, the body weight of mice were measured with the indicated genotypes (n = 15 per each group). DATA are expressed as mean ± SEM

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