Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias

Table 1 Demographic Data of Cases Included in the Study

Case	Sex	AAO	AAD	Brain Weight (g)	Braak Stage	Thal Phase	ABC Score
CTRL1	F	–	68	1330	0	0	A0B0C0
CTRL2	M	–	71	1480	I	0	A0B1C0
CTRL3	F	–	80	1242	II	0	A0B1C0
CTRL4	M	–	89	1448	III	3	A2B2C1
AD1	F	50	66	906	VI	5	A3B3C3
AD2	M	63	73	1269	VI	5	A3B3C3
AD3	M	52	68	1234	VI	5	A3B3C3
AD4	M	63	74	1022	VI	5	A3B3C3
FTDP1^a)	M	55	66	1208	0	0	A0B0C0
FTDP2^b)	M	68	74	1048	II	2	A1B1C1
FTDP3^c)	M	59	66	1399	0	0	A0B0C0
PICK1	M	57	62	1166	III	1	A1B2C1
PICK2	M	54	64	1040	0	3	A2B0C1
PSP1	M	62	74	1580	0	2	A1B0C1
PSP2	F	60	68	1177	0	1	A1B0C1
CBD	F	62	69	1100	0	0	A0B0C0

Abbreviations: CTRL, control; AD, Alzheimer’s disease; FTDP, frontotemporal dementia with parkinsonism linked to chromosome 17; PICK, Pick’s disease; PSP, progressive supranuclear palsy; CBD, corticobasal degeneration; MAPT, microtubule associated protein tau gene locus; M/F, male/female; AAO, age at onset; AAD, age at death
Genetic variants: a) MAPT R406W; b) MAPT Δ280K; c) MAPT 10 + 16

ISSN: 2051-5960