Fig. 7
Quantitative phosphorimaging with [18F]THK-5117 a) Total binding of [18F]THK-5117 to the grey matter of control and tauopathy cases. Experiments were carried out in triplicates. b) Correlation of total [18F]THK-5117 binding in the grey matter, as determined by quantitative phosphorimaging, and tau total load, as determined by AT8 immunohistochemistry in adjacent brain sections. c) [18F]THK-5117 binding to the frontal cortex of case AD1 under constant inhibition of the monoamine oxidases A and B (using 1 μM chlorgylin and L-deprenyl, respectively) and with block of tracer binding using increasing concentrations of flortaucipir (circles) or THK-5117 (triangles) ranging from 0.1–10,000 times Kd. Abbreviations: CTRL, control; AD, Alzheimer’s disease; FTDP, frontotemporal dementia with parkinsonism linked to chromosome 17 (microtubule-associated protein tau mutation); TB, total binding; FC, frontal cortex; TC, temporal cortex; HP, hippocampus