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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

Fig. 5

Schematic representation of the signaling pathways through which full-length OPG-Fc may exert its effects on skeletal muscle. The full-length OPG-Fc binds to RANKL and TRAIL limiting inflammation and apoptotic pathways and also binds to an unknown muscle receptor stimulating SERCA activity and Ca2+ entry thereby favouring Ca2+ cycling and homeostasis and ultimately muscle performance

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Acta Neuropathologica Communications

ISSN: 2051-5960

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