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Table 2 Characteristics of muscle samples with and without pTDP-43 pathology

From: Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Variable pTDP-43 Positive (n = 19) pTDP-43 Negative (n = 38) P-val a
Muscle group 17 Axial, 4 Appendicular b 56 Axial, 57 Appendicular b 0.003
Patient age 64 years (IQR, 58.5–69.5) 59.5 years (IQR, 54.3–66.5) 0.1
Disease duration 1114 days (IQR, 840–2134) 1085 days (IQR, 723–1390) 0.34
CNS TDP+ ROI c 58.3% TDP+ (IQR, 45.5–79.4) 50.0% TDP+ (IQR, 42.3–76.5) 0.67
Men, Women 13 men, 6 women 26 men, 12 women NA
fALS, sALS 3 fALS, 16 sALS 7 fALS, 29 sALS 0.78
C9ALS d 4 C9ALS 9 C9ALS 0.80
Onset site 11 Limb, 5 Bulb, 3 Multifocal 27 Limb, 7 Bulb, 3 Multifocal 0.49
  1. aP-values represent differences using Fisher exact test or Mann-Whitney U test as appropriate (See Methods/ Results). b These numbers do not include three positive “NOS” samples, ten negative “NOS” samples, or negative abdominal wall muscle. c The percentage of brain and spinal cord ROIs positive for TDP-43 pathology as previously described in Cykowski et al., 2017 [17] (see Methods). d C9ALS status accounted for 9 of 10 fALS patients with one patient having an unknown genetic basis