Fig. 2

CD74 association with HLA class II and TILs. a Immunohistochemical staining against HLA class II members and CD74 revealing a heterogeneous expression pattern in tumor cells of BM from melanoma. CD74 positive myeloid cells were excluded from further analysis. b Immunofluorescent doublestaining indicating an overlap of CD74 and HLA class II in the majority of tumors. c Contingency table showing, that more than 50% of CD74 high tumors also showed high levels of HLA class II. d, e and (f) illustrating the association between CD74 expression and TILs in different BM entities