Table 1 Characteristics of subjects
Case | Age at death | Sex | Braak’s cortical NFT stages | Lewy pathology | Brainstem NFT | Comparison of 3R tau % with 4R tau% | Formalin-fixed brain weight (g) | CERAD neuritic plaque score | Brainstem Aβ deposition | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Midbrain | Pons | Midbrain | Pons | |||||||||||||||||||||||||
Superior colliculus | Periaqueductal gray | Linear raphe nucleus | Substantia nigra | Locus coeruleus | Dorsal raphe nucleus | Median raphe nucleus | Neuropil thread | NFT | Total | Superior colliculus | Periaqueductal gray | Linear raphe nucleus | Substantia nigra | Total | Locus coeruleus | Dorsal raphe nucleus | Median raphe nucleus | Reticular formation | Pontine nucleus | |||||||||
Ventral/Dorsal | Medial/Lateral | Midbrain | Pons | Midbrain | Pons | Ventral / Dorsal | Medial/ Lateral | |||||||||||||||||||||
1 | 74 | M | I/II | + (B) | + | + / + | + | +/+ | + | + | + | < | < | < | < | 1310 | 0 | – | – | – | – | – | – | – | – | – | – | – |
2 | 81 | M | I/II | – | + | + / + | + | +/+ | + | + | + | < | < | < | > | 1455 | A | – | – | – | – | – | – | – | – | – | – | – |
3 | 71 | F | I/II | – | + | ++/++ | + | +/++ | +++ | + | ++ | > | > | < | > | 1240 | 0 | – | – | – | – | – | – | – | – | – | – | – |
4 | 77 | M | I/II | – | + | + / + | + | +/+ | + | + | + | < | < | > | > | 1350 | 0 | – | – | – | – | – | – | – | – | – | – | – |
5 | 78 | M | I/II | – | + | + / + | + | +/+ | ++ | + | + | < | > | < | > | 1410 | A | – | – | – | – | – | – | – | – | – | – | – |
6 | 87 | M | I/II | – | + | + / + | + | +/+ | ++ | + | ++ | < | < | < | < | 1375 | B | – | – | – | – | – | – | – | – | – | – | – |
7 | 68 | M | I/II | – | + | + / + | + | +/+ | + | + | + | < | < | < | < | 1390 | 0 | – | – | – | – | – | – | – | – | – | – | – |
8 | 63 | M | I/II | – | + | + / + | + | +/+ | + | + | + | < | > | > | > | 1515 | 0 | – | – | – | – | – | – | – | – | – | – | – |
9 | 86 | F | III/IV | + (B) | + | ++ / + | + | +/++ | +++ | + | ++ | < | > | > | > | 1190 | B | – | – | – | – | – | – | – | – | – | – | – |
10 | 93 | M | III/IV | – | + | ++ / + | +++ | ++/++ | ++ | + | ++ | < | > | > | > | 1430 | B | ++ | ++ | - / + | – | – | ++ | ++ | – | – | – | – |
11 | 100 | F | III/IV | – | + | ++ / + | ++ | +/++ | +++ | + | ++ | > | > | > | > | 1150 | A | – | – | – | – | – | + | + | – | – | – | – |
12 | 83 | F | III/IV | – | +++ | ++ / + | ++ | +/+ | ++ | + | ++ | > | > | > | > | 1100 | B | ++ | ++ | + / ++ | – | +/− | + | + | – | – | – | – |
13 | 86 | M | III/IV | + (T) | + | ++ / + | + | +/+ | + | ++ | +++ | > | < | < | < | 1270 | B | + | + | – | – | – | + | + | – | – | – | – |
14 | 92 | F | III/IV | – | + | + / + | + | +/+ | +++ | ++ | ++ | > | > | > | > | 1130 | B | + | + | – | – | – | – | – | – | – | – | – |
15 | 95 | F | III/IV | – | + | + / + | + | +/++ | + | + | +++ | < | > | > | > | 1260 | C | ++ | ++ | - / + | – | +/− | – | – | – | – | – | – |
16 | 80 | M | III/IV | – | + | + / + | + | +/+ | +++ | + | ++ | > | < | < | < | 1400 | B | + | + | – | – | +/− | – | – | – | – | – | – |
17 | 82 | M | V/VI | – | +++ | +++ / + | ++ | ++/++ | ++ | ++ | +++ | > | > | > | > | 1185 | C | +++ | +++ | + / ++ | + | +/− | +++ | +++ | + | ++ | + | + |
18 | 93 | M | V/VI | – | + | +++ / + | +++ | ++/+ | +++ | +++ | +++ | > | > | > | > | 1080 | C | + | + | - / + | – | +/+ | +++ | +++ | + | ++ | + | – |
19 | 94 | F | V/VI | – | ++ | +++ / + | +++ | ++/+ | +++ | + | +++ | > | > | > | > | 1350 | C | +++ | +++ | - / + | – | ++/+ | + | + | – | – | – | – |
20 | 89 | F | V/VI | – | + | +++ / + | +++ | ++/++ | +++ | ++ | +++ | > | > | > | > | 1300 | B | ++ | ++ | + / ++ | + | – | + | + | – | – | – | – |
21 | 102 | F | V/VI | – | ++ | +++ / + | ++ | +/++ | +++ | + | ++ | < | < | > | > | 1140 | 0 | – | – | – | – | – | – | – | – | – | – | – |
22 | 85 | M | V/VI | – | ++ | +++ / + | +++ | +++/++ | +++ | ++ | +++ | < | < | < | < | 1395 | C | +++ | +++ | + / ++ | + | ++/++ | +++ | +++ | + | ++ | + | + |
23 | 88 | F | V/VI | + (N) | +++ | ++ / + | +++ | +++/++ | +++ | ++ | +++ | > | > | > | > | 1170 | C | +++ | +++ | + /+++ | – | ++/+ | +++ | +++ | + | + | + | + |