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Table 2 Distribution of PrPSc plaque-like deposits (3F4-immunopositive) in the cerebral white matter

From: Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

  frontal cortex temporal cortex parietal cortex occipital cortex hippocampus neostriatum thalamus midbrain medulla oblongata cerebellum
case #1 +++ +++ +++ +++ +++ +++ +++ +++ +++ +++
case #2 + ++ + + + ++ ++ +++ ++ ++
case #3 + + + + + + + + NA 0
case #4 + ++ ++ + + + + + + +
case #5 + + + + + ++ ++ ++ + +
  1. The semi-quantitative evaluation was carried out by averaging the number of plaques among three 200× microscopic fields (1–10 +, 11–20 ++, >21 +++) after selecting the areas with the highest density of PrP deposits. NA: not available