Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

Table 2 Distribution of PrP^Sc plaque-like deposits (3F4-immunopositive) in the cerebral white matter

	frontal cortex	temporal cortex	parietal cortex	occipital cortex	hippocampus	neostriatum	thalamus	midbrain	medulla oblongata	cerebellum
case #1	+++	+++	+++	+++	+++	+++	+++	+++	+++	+++
case #2	+	++	+	+	+	++	++	+++	++	++
case #3	+	+	+	+	+	+	+	+	NA	0
case #4	+	++	++	+	+	+	+	+	+	+
case #5	+	+	+	+	+	++	++	++	+	+

The semi-quantitative evaluation was carried out by averaging the number of plaques among three 200× microscopic fields (1–10 +, 11–20 ++, >21 +++) after selecting the areas with the highest density of PrP deposits. NA: not available

ISSN: 2051-5960