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Table 2 Significant differences in the plasma metabolites of AQP4-Ab NMOSD, RRMS, and MOG-Ab disease

From: Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease

 

AQP4-Ab NMOSD

RRMS

MOG-Ab

Concentration of large LDL particles

↑

  

Size of HDL particles

↑

  

Glucose

↑

  

Cholesterol concentration in large HDL (subclass A)

↑

  

Large LDL particles

↑

  

Small HDL particles

↓

  

Phosphocholine/lipoprotein

↓

  

Scyllo-inositol

↓

  

Lysine/creatinine/creatine

 

↑

 

Histidine

 

↑

 

Large HDL particles

 

↓

 

Lactate

 

↓

 

Unsaturated lipid

 

↓

 

Alanine

 

↓

 

Formate

  

↑

Leucine

  

↑

Myo-inositol

  

↓

  1. Increases and decreases relative to the other two disease classifications are indicated with ↑ and ↓ respectively
  2. Metabolites listed were identified as discriminatory by OPLS-DA