Fig. 4
From: Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case
Basal ganglia tissue sections stained with PHF-1 antibody (left), [F-18]-AV-1451 autoradiography (middle) and blocking with 1 μm unlabeled AV-1451 (right) from 2 AD patients, 2 CTL and 2 non-AD tauopathy subjects. No detectable [F-18]-AV-1451 autoradiography signal was observed in the basal ganglia tissue of any of the subjects studied, including PSP and PiD subjects harboring high burden of tau deposits. AD subjects (AD#1 and AD#2) showed a strong autoradiography signal in the insular cortex adjacent to the putamen where abundant NFTs were present. Abbreviations: AD = Alzheimer’s disease; CTL = control; NFT = neurofibrillary tangles; PiD = Pick’s disease; PSP = Progressive Supranuclear Palsy