Fig. 2

Mean (± SE) TDP-43 morphologies in the anterior cingulate cortex and motor cortex in frontotemporal lobar degeneration (FTLD), frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD-ALS) and amyotrophic lateral sclerosis (ALS). Significant differences were observed in the anterior cingulate cortex across clinicopathological cohorts, with FTLD-ALS cases demonstrating significantly more circumferential TDP-43 inclusions and FTLD cases demonstrating a significantly greater burden of rounded TDP-43 inclusions compared to other groups. *p < 0.05