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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons

Fig. 6

NLRP2 inflammasome mRNA levels are over-expressed in some PSEN2 N141I cells, but it is not driven by mutation. RT-PCR expression of (a) NLRP2, (b) NLRP3, and (c) ASB9 in cholinergic neuroprecursors. d Western blot showing NLRP2, PSEN2 and β-Actin. RT-PCR expression of NLRP2 in Neuroprecursors (e) and BFCNs (f). n = 3, 3 independent experiments with technical triplicates, for all panels. ***, p < .001

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