Fig. 17
From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
pSyk is increased in dystrophic neurites associated with β-amyloid plaques of human AD patients compared to healthy controls. Representative confocal images of dorsolateral frontal cortex sections of human AD (b) were stained with antibodies against Aβ (6E10) (purple), pSyk (525/526) (green), Iba-1 (red) and compared to non-demented control brain sections (a). a The non-demented control (102-year-old, male) does not exhibit any Aβ deposits nor increased Syk activation in neurons. b The AD brain (67-year-old, male) exhibits neurons strongly immunopositive for pSyk (Y525/526). c The AD brain also exhibits dystrophic neurites immunopositive for pSyk (Y525/526) near/within Aβ deposits. The scale bars represent 10 μm