Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Table 3 Grouping of cerebral cortex tissue sections indicates distinct regional distribution and genetic heterogeneity

Measure	Estimate	Standard error	Chi-squared with DF = 1 (P-Value)	OR (95% CI)	Chi-squared (DF) (P-Value)
Phase
I^a	−1.112	0.307	13.10 (0.0003)	0.33 (0.18-0.60)	15.72 (2) (0.0004)
II^b	−0.180	0.344	0.27 (0.6005)	0.84(0.43-1.64)
III/IV^c	1.292	0.270	22.84 (<0.0001)	3.64 (2.14-6.18)
Mutation
Non-C9/GRN^d	1.038	0.448	5.37 (0.0205)	2.82 (1.17-6.80)	7.80 (2) (0.0203)
C9orf72 ^e	−0.996	0.390	6.52 (0.0107)	0.37 (0.17-0.79)
GRN ^f	−0.043	0.465	0.01 (0.9269)	0.95 (0.39-2.38)

^aPhase III/IV is reference group
^bI is reference group
^cII is reference group
^d GRN is reference group
^eNon-C9/GRN is reference group
^f C9orf72 is the reference group
GEE using a proportional odds model for Group 1-2 based on 273 observations. I- orbital frontal cortex; II- mid-frontal, anterior cingulate, entorhinal and superior temporal cortices; III- motor, sensory, and angular cortices; IV- visual cortex. Regions in III and IV are combined due to small number of observations in each region

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