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Table 3 Grouping of cerebral cortex tissue sections indicates distinct regional distribution and genetic heterogeneity

From: Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Measure Estimate Standard error Chi-squared with DF = 1 (P-Value) OR (95% CI) Chi-squared (DF) (P-Value)
Phase
 Ia −1.112 0.307 13.10 (0.0003) 0.33 (0.18-0.60) 15.72
(2)
(0.0004)
 IIb −0.180 0.344 0.27 (0.6005) 0.84(0.43-1.64)
 III/IVc 1.292 0.270 22.84 (<0.0001) 3.64 (2.14-6.18)
Mutation
 Non-C9/GRNd 1.038 0.448 5.37 (0.0205) 2.82 (1.17-6.80) 7.80
(2)
(0.0203)
C9orf72 e −0.996 0.390 6.52 (0.0107) 0.37 (0.17-0.79)
GRN f −0.043 0.465 0.01 (0.9269) 0.95 (0.39-2.38)
  1. aPhase III/IV is reference group
  2. bI is reference group
  3. cII is reference group
  4. d GRN is reference group
  5. eNon-C9/GRN is reference group
  6. f C9orf72 is the reference group
  7. GEE using a proportional odds model for Group 1-2 based on 273 observations. I- orbital frontal cortex; II- mid-frontal, anterior cingulate, entorhinal and superior temporal cortices; III- motor, sensory, and angular cortices; IV- visual cortex. Regions in III and IV are combined due to small number of observations in each region