Fig. 3
From: Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
NeuN is a potential marker of neuronal health. This figure shows the loss of neuronal nuclear proteins in end stage FTLD-TDP (Group 3) compared to normal control cerebral cortex. This includes SFPQ, which is required for pre-mRNA splicing, and it diminishes from normal control to Group 3 cerebral cortex similar to the reduction of NeuN by IHC NeuN. HuC/HuD follows a similar staining pattern in control versus Group 3 cerebral cortex. A NEFH antibody is used to demonstrate axon integrity in the grey matter in control and Group 3 cerebral cortex. Bar = 100 μL