Fig. 1
From: Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?
Kinetic principle of protein aggregation underlies the intercellular aggregate transmission. a Simplified scheme illustrating the kinetics of protein fibrillation and seeded polymerization. Addition of pre-formed fibrils drastically reduced the lag phase. b Illustration of seeded polymerization principle in cell-to-cell aggregate transmission. When protein aggregates are transferred from one cell to another, the transferred aggregates could act as ‘seeds’ in the recipient cells