Fig. 6
From: Long-term neurologic and cardiac correction by intrathecal gene therapy in Pompe disease
Intrathecal administration of AAV9-CAG-hGAA improves cardiac hypertrophy and both serotypes increase the gene expression of cardiac structural proteins. a Left ventricular free wall thickness measurement at the end of diastole by echocardiography M-mode (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 10 per group: **P < 0.01, ***P < 0.001). b Heart to body weight ratio at euthanasia (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 13 per group: *P < 0.05, ***P < 0.001). c Cardiac structural proteins transcript quantification, mRNA up- or down-regulation relative to WT levels (n = 4 per group). Myosin beta heavy chain 7 of cardiac muscle (myh7), actin alpha cardiac muscle 1 (actc1), and actin alpha 1 (acta1). (one-way ANOVA with Newman-Keuls post hoc test; n = 8 to 13 per group: *P < 0.05, **P < 0.01)