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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

Fig. 5

Aberrant synaptic activity in OSK-KI mice. Synaptic plasticity was examined by electrophysiology using hippocampal slices at 4 (a, c) and 8 months (b, d). HFS (100 Hz, 100 pulses) was delivered to the dentate gyrus and fEPSP was recorded for 60 min in the same region in the presence (a, b) and absence (c, d) of 40 μM picrotoxin. Right panels, the levels of fEPSP slope at 60 min were compared. Each bar represents the mean ± SEM. *p < 0.05 versus non-KI and <0.05 versus hetero-KI

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