Fig. 5

Aberrant synaptic activity in OSK-KI mice. Synaptic plasticity was examined by electrophysiology using hippocampal slices at 4 (a, c) and 8 months (b, d). HFS (100 Hz, 100 pulses) was delivered to the dentate gyrus and fEPSP was recorded for 60 min in the same region in the presence (a, b) and absence (c, d) of 40 μM picrotoxin. Right panels, the levels of fEPSP slope at 60 min were compared. Each bar represents the mean ± SEM. *p < 0.05 versus non-KI and <0.05 versus hetero-KI