Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

Table 1 Summary of new tau monoclonal antibodies

Antibody	Antigen	Specificity	Isotype
PHF2	³⁹¹EIVYKpSPVVSGDTpSPRHLS⁴⁰⁹	phosphorylated pS396/S404	IgG₁
PHF15	³⁹¹EIVYKpSPVVSGDTpSPRHLS⁴⁰⁹	phosphorylated pS396/S404	IgG₁
PFH17	³⁹¹EIVYKpSPVVSGDTpSPRHLS⁴⁰⁹	phosphorylated pS396/S404	nd
PHF20	³⁹¹EIVYKpSPVVSGDTpSPRHLS⁴⁰⁹	phosphorylated S404	IgG_2B
PHF22	³⁹¹EIVYKpSPVVSGDTpSPRHLS⁴⁰⁹	phosphorylated S396/S404	IgG₁
1H5	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	prefers phosphorylated tau	IgM
2D1	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylation independent	IgG₁
3C9	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	prefers phosphorylated T205	IgG₁
4A10	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylation-independent	IgG₁
5F2	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylation-independent	IgG₁
6G12	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylated T205	IgG₁
7F2	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylated T205	IgG₁
8G5	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylated T205	IgG₁
10G12	¹⁹³DRSGYSpSPGpSPGpTPGSRSR²¹¹	phosphorylated T205	IgG₁

Listed are the antigens used to generate each antibody, the specificity for each antibody, and their isotypes

ISSN: 2051-5960