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Table 2 Mean +/− SD age at onset, death and duration of illness, and gender composition, for each neuropathological and genetic subgroup of patients. Mean +/− SD and median (in parentheses) post mortem delay interval (PMI) is also presented for each group

From: Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration

Group M/F Onset (y) Death (y) Duration (y) PMI (h)
FTLD-TDP type A (n = 30) 17/13 60.7 ± 6.2 68.7 ± 6.1 8.0 ± 3.0 59.5 ± 33.3 (57)
FTLD-TDP type B (n = 18) 9/9 59.7 ± 8.0 65.2 ± 9.2 5.6 ± 5.5 70.6 ± 40.6 (50)
FTLD-TDP type C (n = 21) 12/9 59.7 ± 7.9 71.8 ± 5.3 12.1 ± 5.1 54.7 ± 35.1 (44)
FTLD-tau (n = 11) 4/7 51.4 ± 6.4 61.4 ± 5.4 10.0 ± 3.1 45.8 ± 24.0 (44)
FTLD C9orf72 expansion (n = 16) 8/8 58.8 ± 5.3 65.7 ± 4.4 6.9 ± 4.6 66.1 ± 21.9 (72)
FTLD GRN mutation (n = 10) 6/4 59.5 ± 6.4 67.9 ± 5.9 8.4 ± 3.7 42.1 ± 29.2 (32)
FTLD No mutation (n = 42) 23/19 60.7 ± 7.9 70.0 ± 8.1 9.3 ± 5.5 62.6 ± 40.2 (48)
FTLD MAPT mutation (n = 11) 4/7 51.4 ± 6.4 61.4 ± 5.4 10.0 ± 3.1 45.8 ± 24.0 (44)
FTLD TBK1 mutation (n = 1) 1/0 62 72 10 97
Healthy Controls (n = 10) 3/7 na 83.3 ± 7.6 na 64.4 ± 35.0 (50.5)