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Table 1 Selected clinical, neuropathological and genetic details on patients studied

From: Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration

case ID# MRC ID# clinical TDP subtype mutation gender PMI (h) Onset (y) Death (y) Duration (y)
1* BBN_5681 bvFTD FTLD-TDP A C9ORF72 M 74 49 58 9
2* BBN_5706 bvFTD FTLD-TDP A C9ORF72 M 28 60 68 8
3* BBN_5719 bvFTD FTLD-TDP A C9ORF72 F 74 59 64 5
4* BBN_5752 bvFTD FTLD-TDP A C9ORF72 M na 64 72 8
5 BBN_14793 bvFTD FTLD-TDP A C9ORF72 M 81 54 65 11
6 BBN_5756 FbvTD FTLD-TDP B C9ORF72 F 48 52 70 18
7* BBN_5771 FTD + MND FTLD-TDP B C9ORF72 F 50 63 65 2
8* BBN_5772 FTD + MND FTLD-TDP B C9ORF72 F 50 68 73 5
9 BBN_5691 FTD + MND FTLD-TDP B C9ORF72 M 72 60 62 2
10* BBN_5663 FTD + MND FTLD-TDP B C9ORF72 M 36 57 59 2
11* BBN_5742 PNFA FTLD-TDP A GRN V452WfsX38 M 57 66 71 5
12 BBN_10260 PNFA FTLD-TDP A GRN V452WfsX38 M 25 62 72 10
13* BBN_5660 bvFTD FTLD-TDP A GRN V452WfsX38 F 13 53 71 18
14 BBN_5773 bvFTD FTLD-TDP A GRN Q130SfsX124 M 74 66 73 7
15 BBN_5715 PNFA FTLD-TDP A GRN Q130SfsX124 F 24 63 71 8
16* BBN_5727 PNFA FTLD-TDP A GRN C31LfsX34 M 104 66 73 7
17 BBN_5718 bvFTD FTLD-TDP A GRN R493X M 35 59 66 7
18 BBN_5675 bvFTD FTLD-TDP A GRNR493X F 12 51 61 10
19 BBN_5686 bvFTD FTLD-TDP A GRN Q468X F 48 60 66 6
20 BBN_5734 bvFTD FTLD-TDP A none M 48 69 75 6
21* BBN_5685 PNFA FTLD-TDP A none M 19 68 78 10
22 BBN_5757 PNFA FTLD-TDP A none F 72 66 77 11
23 BBN_5753 bvFTD FTLD-TDP A none F 46 66 72 6
24 BBN005.28193 bvFTD FTLD-TDP A none F 144 67 72 5
25 BBN005.29059 bvFTD FTLD-TDP A none M 52 67 71 4
26 BBN_5661 FTD + MND FTLD-TDP B none M 21 43 45 2
27* BBN_5676 FTD + MND FTLD-TDP B none M na 60 68 8
28* BBN_5701 FTD + MND FTLD-TDP B none M 30 45 51 6
29* BBN_5721 FTD + MND FTLD-TDP B none M 87 58 69 11
30 BBN_5732 FTD + MND FTLD-TDP B none F 164 50 52 3
31* BBN_5764 FTD + MND FTLD-TDP B none M 110 61 65 4
32 BBN_24314 FTD + MND FTLD-TDP B none F 133 61 63 2
33 BBN005.28645 FTD + MND FTLD-TDP B none M 114 64 69 5
34 BBN_5678 SD FTLD-TDP C none M 48 54 68 14
35 BBN_5708 SD FTLD-TDP C none F 28 55 66 11
36* BBN_5720 SD FTLD-TDP C none M 59 60 75 15
37 BBN_5726 SD FTLD-TDP C none F 104 56 67 11
38 BBN_5736 SD FTLD-TDP C none F 168 70 72 2
39* BBN_5731 SD FTLD-TDP C none M 44 71 77 6
40 BBN_16418 SD FTLD-TDP C none M 29 56 68 12
41 BBN_19623 SD FTLD-TDP C none F 86 68 82 14
42 BBN005.26066 SD FTLD-TDP C none M 59 52 66 14
43 BBN005.28698 SD FTLD-TDP C none M 35 57 77 20
44 BBN_5659 bvFTD FTLD-tau MAPT exon 10 + 16 M 46 50 61 11
45 BBN_5696 bvFTD FTLD-tau MAPT exon 10 + 16 F 52 46 58 12
46 BBN_5699 bvFTD FTLD-tau MAPT exon 10 + 16 M 30 43 55 12
47 BBN_5717 bvFTD FTLD-tau MAPT exon 10 + 16 F 23 52 65 13
48 BBN_5744 bvFTD FTLD-tau MAPT exon 10 + 16 F 33 50 60 10
49* BBN_5733 bvFTD FTLD-tau MAPT exon 10 + 16 M 24 46 53 7
50 BBN_5760 bvFTD FTLD-tau MAPT exon 10 + 16 F 96 48 63 15
51 BBN_5763 bvFTD FTLD-tau MAPT exon 10 + 16 F 48 52 58 6
52 BBN_6081 bvFTD FTLD-tau MAPT exon 10 + 16 F 26 53 63 10
53 BBN005.29180 bvFTD FTLD-tau MAPT exon 10 + 16 F 83 60 69 9
54 BBN_5710 bvFTD FTLD-tau MAPT exon 10 + 13 M 43 65 70 5
55 BBN_3109 Control none none F 72 na 76 na
56 BBN_3124 Control none none F 44 na 82 na
57 BBN_3126 Control none none M 52 na 80 na
58* BBN_3378 Control none none F 48 na 77 na
59 BBN_3447 Control none none F 41 na 80 na
60 BBN_20608 Control none none F 130 na 76 na
61 BBN_3337 Control none none F 12 na 87 na
62* BBN_3430 Control none none M 49 na 84 na
63 BBN_25922 Control none none F 103 na 100 na
64 BBN_25974 Control none none M 93 na 91 na
65 BBN_8556 bvFTD FTLD-TDP A C9orf72 M 77 53 63 10
66 BBN_8109 PNFA FLTD-TDP A C9orf72 F 85 56 67 11
67 BBN_20082 PNFA FTLD-TDP A C9orf72 F 63 57 62 5
68 BBN007.29537 bvFTD FTDL-TDP A C9orf72 M 52 66 71 5
69 BBN007.26830 bvFTD FTLD-TDP A C9orf72 F 107 58 66 8
70 BBN_11628 bvFTD FLTD-TDP A TBK1 M 97 62 72 10
71 BBN_11698 bvFTD FTLD-TDP A none F 85 57 63 6
72 BBN_11574 bvFTD FTDL-TDP A none F 8 70 83 13
73 BBN_12507 bvFTD FTLD-TDP A none M 93 57 62 5
74 BBN007.29538 bvFTD FLTD-TDP A GRN C31LfsX34 M 29 49 55 6
75 BBN_12169 bvFTD FTLD-TDP B C9orf72 F 94 64 66 2
76 BBN_12136 MND FTLD-TDP B none M 70 67 69 2
77 BBN_11773 MND FTLD-TDP B none F 30 75 77 2
78 BBN_12451 FTD/MND FTLD-TDP B none F 46 63 67 4
79 BBN_12331 bvFTD FTLD-TDP B none F 45 63 83 20
80 BBN_12480 SD FTLD-TDP C none F 38 58 73 15
81 BBN_12524 SD FTLD-TDP C none F 84 59 73 14
82 BBN_11594 SD FTLD-TDP C none M 27 64 78 14
83 BBN_11883 SD FTLD-TDP C none M 19 64 74 10
84 BBN_8614 SD FTLD-TDP C none M 52 50 65 15
85 BBN_12300 SD FTLD-TDP C none M 71 61 66 5
86 BBN007.26814 SD FTLD-TDP C none M 76 44 67 23
87 BBN007.26851 PNFA FTLD-TDP C none F 26 77 80 3
88 BBN007.26876 SD FTLD-TDP C none F 31 58 72 14
89 BBN007.26890 SD FTLD-TDP C none M 40 67 76 9
90 BBN007.29539 SD FTLD-TDP C none F 25 52 65 13
  1. PMI Post mortem delay interval, na data unavailable. Cases with asterix denote that new blocks were cut for the study from long-standing archived fixed tissues
  2. The asterix (*) denotes cases where new tissue blocks were cut from archived samples, the original diagnostic samples no longer being available for analysis
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Acta Neuropathologica Communications

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