Fig. 6

Improved cognitive function of APPPS1 mice upon iP deficiency. a Aged APPPS1;LMP7^+/+ and respective littermate APPPS1;LMP7^−/− mice underwent behavioral tests for cognition, LMP7^+/+ and LMP7^−/− mice served as controls. Percentage of time spent exploring the novel object and percentage of visits to the new object in the Novel object recognition test (n = 8–10 mice per group; duration: LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0475; visits: LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0209; one-way ANOVA followed by Bonferroni post-tests). b Quantification of recorded track lengths and respective mouse activity of APPPS1;LMP7^+/+ and respective littermate APPPS1;LMP7^−/− mice analyzed in the Open field arena (n = 8–10 mice per group; p > p 0.05; one-way ANOVA followed by Bonferroni post-tests). c Latency to target and number of errors during training trials during the Barnes maze paradigm (n = 8–10 mice per group; day 4: LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0033; LMP7^+/+ vs. APPPS1;LMP7^−/−: p = 0.2096; two-way ANOVA followed by Bonferroni post-tests). d Short-term and long-term memory retention trail: Quantification of latency to reach the target and total time spent in the target zone during the Barnes maze paradigm (n = 8–10 mice per group; short-term retention: LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0067; LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0322; long-term retention: LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0022; APPPS1;LMP7^−/− vs. APPPS1;LMP7^+/+: p = 0.0548; LMP7^+/+ vs. APPPS1;LMP7^+/+: p = 0.0322; LMP7^+/+ vs. APPPS1;LMP7^−/−: p = 0.0178; one-way ANOVA followed by Bonferroni post-tests)