Fig. 5

Inflammatory Response a Representative striatal images of Olig001-α-syn injected monkeys (top row) or Olig001-GFP injected monkeys (bottom row). An inflammatory response is seen by HLA-DR+ microglia in white matter tracts of Olig001-α-syn injected monkeys, exclusively covering the entire region corresponding to rAAV- Olig001-mediated α-syn expression. High magnification images show that the morphology of activated microglia. Conversely, in GFP-injected animals, a minimal inflammatory response is seen only in the area of the injection site, not covering the entire region of GFP expression (scale bar 500 μm). High magnification images show that activated microglia are only seen in the immediate vicinity of the injection site (scale bar 10 μm). b Activated microglia area also seen in the substantia nigra of Olig001-α-syn injected monkeys, where as the microglia seen in GFP-injected monkeys are in the resting state, shown by a ramified morphology (scale bar low magnification 500 μm, high magnification 100 μm)