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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery

Fig. 7

Multidimensional scale mapping derived copy number alterations forms unique prognostic molecular subtypes. a Glioblastoma, IDH-wildtype, WHO grade IV can be divided into three subtypes (W1–3). b The IDH-mutant astrocytic glioma/glioblastoma cluster can be divided into three molecular subtypes. These molecular subtypes are reflective of overall survival, and independent of WHO grade. c Dividing the molecular subtypes into either poor (M1/M2) or favorable (M3) groups is significantly associated with survival (Hazard ratio [HR] 3.28, 95% confidence interval [CI] 1.62–6.62, p = 0.001). This Hazard ratio is slightly larger, but comparable to dividing this cluster into WHO grade II versus WHO grade III/IV (HR 2.01, 95% CI 1.06–4.02, p = 0.036). P values determined using Cox proportional hazard regression

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Acta Neuropathologica Communications

ISSN: 2051-5960

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