Fig. 7

Age-dependent accumulation of α-Syn toxicity in the striatum. a Coronal brain sections containing rostral-dorsal striatum (6 μm, paraffin embedded) of A53T α-Syn mouse at 2, 8 and 12 months of age, or control brain section at 12 months old, immunoreacted with anti-α-Syn antibody (syn - 303). Scale bar, 50 μm b. Quantification of α-Syn signal in striatum of n = 4 mice at each age group. Mean ± SD. *, < 0.05, one-way ANOVA c. Coronal brain sections of A53T α-Syn and control mouse brains, at 12 months of age. Immunoreacted with anti-α-Syn antibody followed by Avidin/Biotin detection. Scale bar, 10 μm. Square present area of magnification