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Table 1 Basal dialysate levels (nM) of DA and its metabolites DOPAC, 3-MT and HVA monitored using in vivo microdialysis in the dorsal striatum of 19-month-old G2019S knock-in mice (G2019S KI) and wild-type littermates (WT)

From: Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

genotype

 

DA

DOPAC

HVA

3-MT

DOPAC/DA

HVA/DA

3-MT/DA

WT

nM

0.28 ± 0.06

47.31 ± 15.98

82.39 ± 21.44

0.99 ± 0.51

247.63 ± 112.25

242.30 ± 36.65

2.96 ± 0.87

G2019S KI

nM

0.36 ± 0.06

22.12 ± 5.63

54.74 ± 11.63

0.42 ± 0.082

48.65 ± 10.39

114.00 ± 36.50*

1.14 ± 0.24*

  1. *p < 0.05, significantly different from WT The metabolite/DA ratios are also reported. Data are means ± SEM of 11–15 determinations per group and were analyzed using the Student t-test, two-tailed for unpaired data
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Acta Neuropathologica Communications

ISSN: 2051-5960

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