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Table 1 Basal dialysate levels (nM) of DA and its metabolites DOPAC, 3-MT and HVA monitored using in vivo microdialysis in the dorsal striatum of 19-month-old G2019S knock-in mice (G2019S KI) and wild-type littermates (WT)

From: Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

genotype   DA DOPAC HVA 3-MT DOPAC/DA HVA/DA 3-MT/DA
WT nM 0.28 ± 0.06 47.31 ± 15.98 82.39 ± 21.44 0.99 ± 0.51 247.63 ± 112.25 242.30 ± 36.65 2.96 ± 0.87
G2019S KI nM 0.36 ± 0.06 22.12 ± 5.63 54.74 ± 11.63 0.42 ± 0.082 48.65 ± 10.39 114.00 ± 36.50* 1.14 ± 0.24*
  1. *p < 0.05, significantly different from WT The metabolite/DA ratios are also reported. Data are means ± SEM of 11–15 determinations per group and were analyzed using the Student t-test, two-tailed for unpaired data