Fig. 3
From: The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease
Variability in the electron dense material of RFs. a Large RF is composed of two types of materials, one homogeneously dark and other with moderate electron density Note that astrocyte has two nuclear profiles (N). a1 Enlarged boxed region in (a), showing heterogeneity of RFs. b Central large RF is surrounded by many small RFs. b1) enlarged boxed area in (b). Note that large RF (RF) is encircled by membranes. Small neighboring RFs (arrows, only some marked) are not membrane-bound. KI homozygous 1 year-old mice. Scale bars: 5 μm