Fig. 4

Characterization and result of the functional analysis of module M3 (brown). a M3 is significantly associated to Novel Object (p > 2.8E-02, r = −0.52), Novel Place (p > 1.9E-02, r = −0.53) and pSer31Th (p > 3.0E-03, r = −0.64). b Heatmap analysis of ME expression levels show that genes in M3 are largely driven by NSC transplantation, being upregulated in Veh treated groups and downregulated in NSC groups. c Cell-type specific expression analysis (CSEA) shows that M3 is highly enriched in genes expressed in cholinergic neurons. d The modular network organization of M3 depicted by VisANT [46]. Each green node represents a unique gene in M3 and the gene-gene interactions depicted in cyan lines. The red center node corresponds to the module hubgene Elavl4 with highest intramodular connectivity holding together the entire network as a functional unit (enlarged figure: Additional file 2: Figure S7)