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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice

Fig. 3

Characterization and result of the functional analysis of Module 2 (blue). a M2 is significantly associated to Novel Object (p > 2.8E-04, r = −0.74), Novel Place (p > 1.7E-02, r = −0.54) as well as mBDNF (p > 1.2E-03, r = −0.68), GLT1 (p > 9.0E-03, r = −0.58) and pSer31Th (p > 5.2E-05, r = −0.79). b Heatmap analysis of ME expression levels show that genes in M2 are largely increased in Veh groups and downregulated in NSC-transplanted groups. c Cell-type specific expression analysis (CSEA) show that M2 is enriched in genes expressed in cortical neurons and immune cells. d Representative functional annotation terms of M2 (all functional annotations can be found in Additional files 7, 8, 9 and 11)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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