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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: A novel form of necrosis, TRIAD, occurs in human Huntington’s disease

Fig. 6

TRIAD-specific changes in cortical neurons of human HD patients. a ERs (er) were extremely enlarged in cortical neurons of a HD patient (grade III). Mitochondria were also enlarged (mi). b Ribosomes still attach to the outer surface of enlarged ER (er), and could be discriminated from mitochondria (mi). c Golgi apparatus (gol) was also enlarged. d At a lower magnification, a number of ER was enlarged while the nucleus was almost normal. Autophagosomes were not detected in the cell. Neurite is indicated as nrt. EM images of other three patients (grade 4) are shown in Additional file 1: Figure S1

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