Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Fig. 3

AAV1/2-A53T-aSyn SN delivery results in reduction of DA and higher DA turnover. a-c Diagrams show HPLC analyses of DA and dopaminergic metabolite levels of mouse striatum. Each bar represents the relative level in percent comparing the right (injected) side to the contralateral (non-injected side). 10 weeks after AAV1/2 injection a significant reduction of DA level is visible in AAV1/2-A53T-aSyn mice (white bar) as compared to the AAV1/2-EV group (black bar) (a). A significant reduction of DOPAC is also found in AAV1/2-A53T-aSyn treated animal (b). The elevated ratio of HVA/DA (c) indicates a higher DA turnover in AAV1/2-A53T-aSyn mice. **P < 0.01; ***P < 0.001

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us