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Table 1 Characteristics of the 3D reconstructed AxDs

From: High plasticity of axonal pathology in Alzheimer’s disease mouse models

  dE9xGFP-M
Type of axon Lifetime (days) Disappearance of AxDs at the end of the imaging period Disappearance of the parent axon Reformation of AxDs Maximum AxD volume (μm3) Maximum AxD size ratio Axonal sprouting
Dys 1 TB >168 No No No 2049 22.98 Yes
Dys 2 EPB >75 Yes Yes No 414 19.40 No
Dys 3 EPB 3a: >10
3b: 62
3c: >6
No No Yes 3a: 3081
3b: 646
3c: 697
3a: 39
3b: 8.18
3c: 8.82
Yes
Dys 4 TB 4a: >10
4b: 116
Yes No Yes 4a: 952
4b: 789
4a: 21.3
4b: 17.64
Yes
Dys 5 EPB >155 Yes Yes No 76 3.57 No
Dys 6 EPB 120 Yes Yes No 310 10.33 No
Dys 7 EPB >110 No No No 150 4.83 No
Dys 8 EPB >168 No No No 176 5.33 No
Dys 9 EPB >168 No No No 165 12.58 No
Dys 10 EPB >49 No No No 458 6.83 No
  APP-PS1xGFP-M
Type of axon Lifetime (days) Disappearance of AxDs at the end of the imaging period Disappearance of the parent axon Reformation of AxDs Maximum AxD volume (μm3) Maximum AxD size ratio Axonal sprouting Regrowth
Dys 1 EPB 110 Yes No No 778 20.2 Yes No
Dys 2 EPB 2a: 47
2b: >88
No No Yes 2a: 565
2b: 669
2a: 9.81
2b: 35.20
Yes No
Dys 3 TB >63 Yes Yes No 514 24.49 Yes No
Dys 4 EPB 160 Yes Yes No 2814 20.14 Yes No
Dys 5 TB >138 No No No 565 14.77 Yes No
Dys 6 EPB 124 Yes Yes No 755 16.01 No No
Dys 7 TB 95 Yes Yes No 565 4.03 Yes No
Dys 8 TB 101 Yes Yes No 1496 27.46 Yes No
Dys 9 TB >47 Yes No No 512 21.30 No Yes
Dys 10 EPB 59 Yes Yes No 221 8.10 No No
Dys 11 EPB 51 Yes No No 64 5.00 No No
Dys 12 EPB 72 Yes Yes No 259 9.45 No No
Dys 13 TB >131 No No No 274 18.84 No Yes
Dys 14 EPB 14a: 29
14b: >40
No No Yes 14a: 32
14b: 65
14a: 2.45
14b: 7.20
No No
Dys 15 EPB 15a: >23
15b: 117
Yes Yes Yes 15a: 116
15b: 203
15a: 14.43
15b: 21.05
No No
Dys 16 TB 37 Yes Yes No 48 4.80 No No