High plasticity of axonal pathology in Alzheimer’s disease mouse models

Table 1 Characteristics of the 3D reconstructed AxDs

	dE9xGFP-M
	Type of axon	Lifetime (days)	Disappearance of AxDs at the end of the imaging period	Disappearance of the parent axon	Reformation of AxDs	Maximum AxD volume (μm³)	Maximum AxD size ratio	Axonal sprouting
Dys 1	TB	>168	No	No	No	2049	22.98	Yes
Dys 2	EPB	>75	Yes	Yes	No	414	19.40	No
Dys 3	EPB	3a: >10 3b: 62 3c: >6	No	No	Yes	3a: 3081 3b: 646 3c: 697	3a: 39 3b: 8.18 3c: 8.82	Yes
Dys 4	TB	4a: >10 4b: 116	Yes	No	Yes	4a: 952 4b: 789	4a: 21.3 4b: 17.64	Yes
Dys 5	EPB	>155	Yes	Yes	No	76	3.57	No
Dys 6	EPB	120	Yes	Yes	No	310	10.33	No
Dys 7	EPB	>110	No	No	No	150	4.83	No
Dys 8	EPB	>168	No	No	No	176	5.33	No
Dys 9	EPB	>168	No	No	No	165	12.58	No
Dys 10	EPB	>49	No	No	No	458	6.83	No
	APP-PS1xGFP-M
	Type of axon	Lifetime (days)	Disappearance of AxDs at the end of the imaging period	Disappearance of the parent axon	Reformation of AxDs	Maximum AxD volume (μm³)	Maximum AxD size ratio	Axonal sprouting	Regrowth
Dys 1	EPB	110	Yes	No	No	778	20.2	Yes	No
Dys 2	EPB	2a: 47 2b: >88	No	No	Yes	2a: 565 2b: 669	2a: 9.81 2b: 35.20	Yes	No
Dys 3	TB	>63	Yes	Yes	No	514	24.49	Yes	No
Dys 4	EPB	160	Yes	Yes	No	2814	20.14	Yes	No
Dys 5	TB	>138	No	No	No	565	14.77	Yes	No
Dys 6	EPB	124	Yes	Yes	No	755	16.01	No	No
Dys 7	TB	95	Yes	Yes	No	565	4.03	Yes	No
Dys 8	TB	101	Yes	Yes	No	1496	27.46	Yes	No
Dys 9	TB	>47	Yes	No	No	512	21.30	No	Yes
Dys 10	EPB	59	Yes	Yes	No	221	8.10	No	No
Dys 11	EPB	51	Yes	No	No	64	5.00	No	No
Dys 12	EPB	72	Yes	Yes	No	259	9.45	No	No
Dys 13	TB	>131	No	No	No	274	18.84	No	Yes
Dys 14	EPB	14a: 29 14b: >40	No	No	Yes	14a: 32 14b: 65	14a: 2.45 14b: 7.20	No	No
Dys 15	EPB	15a: >23 15b: 117	Yes	Yes	Yes	15a: 116 15b: 203	15a: 14.43 15b: 21.05	No	No
Dys 16	TB	37	Yes	Yes	No	48	4.80	No	No

ISSN: 2051-5960