Fig. 4

Expression of the TMEM106B transgene results in elevated TMEM106B levels in aged PGRN−/− mice. a Transgene expression does not lead to changes in TMEM106B protein levels in young PGRN−/− mice of 4–5 months old compared to littermate WT controls. Cortical lysates from the transgenic and littermate controls were subjected to Western blot with anti- TMEM106B antibodies. b TMEM106B transgene expression leads to increased TMEM106B protein levels in aged PGRN−/− mice (17-20 months old). n = 3, student’s t-test. *, p < 0.05; ns, no significance