Table 4 Clinical pathologic correlations of select LC neuronal transcripts dysregulated in aMCI and AD
From: Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease
transcript | GCS | MMSE | Braak | NIA-Reagan | CERAD |
|---|---|---|---|---|---|
cytc1 | r = 0.64 (p < 0.0001) | r = 0.48 (p = 0.003) | r = −0.50 (p = 0.003) | r = −0.41 (p = 0.02) | r = −0.48 (p = 0.01) |
nrf1 | r = 0.57 (p = 0.0003) | r = 0.37 (p = 0.04) | r = −0.43 (p = 0.08) | r = −0.39 (p = 0.06) | r = −0.50 (p = 0.003) |
gpx1 | r = 0.54 (p = 0.008) | r = 0.44 (p = 0.008) | r = −0.42 (p = 0.02) | r = −0.42 (p = 0.01) | r = −0.39 (p = 0.02) |
map1b | r = 0.59 (p = 0.0006) | r = 0.35 (p = 0.03) | r = −0.43 (p = 0.01) | r = −0.33 (p = 0.2) | r = −0.32 (p = 0.09) |
nf-h | r = 0.54 (p = 0.0007) | r = 0.51 (p = 0.001) | r = −0.55 (p < 0.001) | r = −0.49 (p = 0.005) | r = −0.45 (p = 0.006) |
ntn1 | r = 0.52 (p = 0.0008) | r = 0.44 (p = 0.007) | r = −0.41 (p < 0.01) | r = −0.40 (p = 0.02) | r = −0.47 (p = 0.006) |
synpo | r = 0.65 (p < 0.0001) | r = 0.52 (p < 0.001) | r = −0.58 (p < 0.001) | r = −0.47 (p = 0.008) | r = −0.45 (p = 0.005) |
sod1 | r = 0.22 (p = 0.1) | r = −0.11 (p = 0.5) | r = −0.18 (p = 0.6) | r = −0.09 (p = 0.6) | r = −0.28 (p = 0.1) |