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Table 4 Clinical pathologic correlations of select LC neuronal transcripts dysregulated in aMCI and AD

From: Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

transcript GCS MMSE Braak NIA-Reagan CERAD
cytc1 r = 0.64 (p < 0.0001) r = 0.48 (p = 0.003) r = −0.50 (p = 0.003) r = −0.41 (p = 0.02) r = −0.48 (p = 0.01)
nrf1 r = 0.57 (p = 0.0003) r = 0.37 (p = 0.04) r = −0.43 (p = 0.08) r = −0.39 (p = 0.06) r = −0.50 (p = 0.003)
gpx1 r = 0.54 (p = 0.008) r = 0.44 (p = 0.008) r = −0.42 (p = 0.02) r = −0.42 (p = 0.01) r = −0.39 (p = 0.02)
map1b r = 0.59 (p = 0.0006) r = 0.35 (p = 0.03) r = −0.43 (p = 0.01) r = −0.33 (p = 0.2) r = −0.32 (p = 0.09)
nf-h r = 0.54 (p = 0.0007) r = 0.51 (p = 0.001) r = −0.55 (p < 0.001) r = −0.49 (p = 0.005) r = −0.45 (p = 0.006)
ntn1 r = 0.52 (p = 0.0008) r = 0.44 (p = 0.007) r = −0.41 (p < 0.01) r = −0.40 (p = 0.02) r = −0.47 (p = 0.006)
synpo r = 0.65 (p < 0.0001) r = 0.52 (p < 0.001) r = −0.58 (p < 0.001) r = −0.47 (p = 0.008) r = −0.45 (p = 0.005)
sod1 r = 0.22 (p = 0.1) r = −0.11 (p = 0.5) r = −0.18 (p = 0.6) r = −0.09 (p = 0.6) r = −0.28 (p = 0.1)