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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

Fig. 5

PCBP1 mRNA targets have larger UTRs and share a common recognition sequence. a The average length of the 5′UTRs present in the top 50 high and low enriched genes was compared to the average length of the mouse 5′UTRome. Wilcoxon rank sum test, p ≤ 0,001. The same analysis was performed in (b) with the 3′UTR present in the top 50 genes of high and low enriched genes. Wilcoxon rank sum test; p ≤ 0,001. c PCBP1 mRNA targets share a common recognition sequence that is rich in poly(C) repeat stretches. This RNA motif was identified by subjecting the most stringent set of PCBP1 targets, above ≥ 2-fold, to MEME analysis. d Table with statistics showing the enrichment of the RNA motif in values

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Acta Neuropathologica Communications

ISSN: 2051-5960

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