Fig. 3
From: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
The distribution and nature of major heteroplasmic mtDNA variation within 1363 cases from the MRC Brain Bank Tissue Resource. a Top left – The mean number of heteroplasmic variants per sample in each cohort. b Top right - The distribution of heteroplasmic fraction (ratio of mutant to wild-type allele) for heteroplasmic variants for each disease cohort. c Bottom left – The mean number of heteroplasmic point mutations by age for each disease cohort. d Bottom right – The mean heteroplasmic fraction by age for each disease cohort. Key – AD –Alzheimer’s disease, CJD – Creutzfeldt Jacob Disease, DLB-PD – Dementia with Lewy Bodies or Parkinson’s disease, FTD-ALS – Frontotemporal Dementia or Amyotrophic Lateral Sclerosis