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Table 1 Bielschowsky assessments of neuritic plaque densities

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

Algorithm mCERADSOT mCERADmode CERAD
Regions assessed MFL, MTG, STG, IPL, ACG, PCG, PRC, PVC MFL, MTG, STG, IPL MFL, MTG, STG, IPL
Regional assessments 8 regional averages (mean) of 30 intra-regional numerica assessments (each 0 ≤ x ≤ 3) 4 regional averages (mode) of 30 intra-regional categorical assessments (none, sparse, moderate, frequent) 1 global assessment from region of highest involvement (none, sparse, moderate, frequent)
Case dichotomy Any region >1.5 is abnormal Any region = moderate or frequent is abnormal moderate or frequent is abnormal
  1. MFL midfrontal lobe, MTG middle temporal gyrus, STG superior temporal gyrus, IPL inferior parietal lobe, ACG anterior cingulate gyrus, PCG posterior cingulate gyrus, PRC Precuneus, PVC primary visual cortex
  2. aEach assessment was recorded as 0 = none (no plaques per 100x field of view), 1 = sparse (1-5 plaques), 2 = moderate (6-19 plaques) or 3 = frequent (20 or more plaques). A total of 240 cortical assessments were recorded for each case