Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

Table 1 Bielschowsky assessments of neuritic plaque densities

Algorithm	mCERAD_SOT	mCERAD_mode	CERAD
Regions assessed	MFL, MTG, STG, IPL, ACG, PCG, PRC, PVC	MFL, MTG, STG, IPL	MFL, MTG, STG, IPL
Regional assessments	8 regional averages (mean) of 30 intra-regional numeric^a assessments (each 0 ≤ x ≤ 3)	4 regional averages (mode) of 30 intra-regional categorical assessments (none, sparse, moderate, frequent)	1 global assessment from region of highest involvement (none, sparse, moderate, frequent)
Case dichotomy	Any region >1.5 is abnormal	Any region = moderate or frequent is abnormal	moderate or frequent is abnormal

MFL midfrontal lobe, MTG middle temporal gyrus, STG superior temporal gyrus, IPL inferior parietal lobe, ACG anterior cingulate gyrus, PCG posterior cingulate gyrus, PRC Precuneus, PVC primary visual cortex
^aEach assessment was recorded as 0 = none (no plaques per 100x field of view), 1 = sparse (1-5 plaques), 2 = moderate (6-19 plaques) or 3 = frequent (20 or more plaques). A total of 240 cortical assessments were recorded for each case

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