Fig. 3
From: The identification of human pituitary adenoma-initiating cells
CD15 enriches for pituitary adenoma-initiating cells. Pituitary developmental genes (a) Pax7 (n = 22, P < 0.005) and (b) Sox2 (n = 22, P < 0.001) are highly expressed in CD15high adenomas compared to CD15low tumors. c Representative flow cytometric plot for enrichment of CD15+ PAICs. d Photomicrograph comparing sphere formation in CD15+ PAICs and CD15- cells (×100, Scale bar = 100 μm). e CD15+ PAICs maintain a higher sphere formation capacity when compared to CD15- cells (n = 2, P < 0.01). f CD15high pituitary adenomas contain a higher sphere formation rate when compared to CD15low tumors, irrespective of adenoma subtype (n = 10, P < 0.01)