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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology

Fig. 3

Presence of UPR activation markers and GVD in the frontal cortex of an unusual GSS case carrying a PRNP Q227X mutation (case #14). a Immunohistochemical detection of PrP using the 3F4 antibody in the frontal cortex. b Detection of hyperphosphorylated tau (AT8 antibody) in the frontal cortex. c Localization of pPERK in GVD structures (see inset) in the frontal cortex. d Immunohistochemical detection of CK1δ shows staining of GVD structures in the frontal cortex. e Immunohistochemical staining for pIRE1α shows absence of pIRE1α immunoreactivity. f Immunohistochemical detection of PrP using the 3F4 antibody in the frontal cortex shows intraneuronal detection in granular structures resembling GVD. Insets show higher magnification of indicated area. a-f Brown staining with DAB, blue staining of the nucleus with haematoxylin. Bar a, b 100 μm; c-f 20 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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