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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology

Fig. 2

Immunohistochemical detection of pIRE1α, pPERK, and CK1δ in AD, vCJD and control brain tissue. Representative pictures are shown of the immunohistochemical detection of pIRE1α (a-d), pPERK (e-h) and CK1δ (i-l) in the hippocampus or frontal cortex of AD, vCJD and non-demented control cases. Immunohistochemical detection of pIRE1α (a), pPERK (e) and CK1δ (i) in neurons in the CA1 region of the hippocampus of a sporadic AD case (case #61). Immunohistochemical detection of pIRE1α (b), pPERK (f) and CK1δ (j) in the frontal cortex of a familial AD case (case #59). Immunohistochemical detection of pIRE1α (c), pPERK (g) and CK1δ (k) in the frontal cortex of a case with vCJD (case #20). Immunohistochemical detection of pIRE1α (d), pPERK (h) and CK1δ (i) in the frontal cortex of a non-demented control case (case #5). The inset (e) shows a typical granular staining which can be referred to as GVD. Immunohistochemical detection is visualized by DAB (brown staining) and nuclei are counterstained with haematoxylin (blue staining). Bar a-l 50 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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