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Table 2 Simultaneous equation regression model of the direct and total effects of age and years of exposure to RHI on CD68 cell density and tau pathology (AT8 tau density)

From: Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

  Standardized direct effects Standardized total effects
Effect/Std error/t value/p value Effect/Std error/t value/p value
CD68 Density AT8 Tau Density CD68 Density AT8 Tau Density
Age −0.0195 0.5125 0.006044 0.5136
0.1003 0.0682 0.1009 0.0691
−0.1948 7.5184 0.0599 7.4306
0.8456 <.0001 0.9523 <.0001
RHI Exposure (Years) 0.3911 0.4614 0.4178 0.5349
0.0852 0.071 0.0917 0.0681
4.5911 6.4999 4.5551 7.8586
<.0001 <.0001 <.0001 <.0001
CD68 Density   0.1759   0.1774
0.0499   0.0507
3.5271   3.5005
<.0001   <.0001
AT8 Tau Density 0.0498   0.0503  
0.0112 0.0114  
4.4363 4.4058  
<.0001 <.0001  
  1. Simultaneous equation regression was used to analyze the direct and total effects. Bolded numbers represent significant p values. Visual pathway analysis can be found in Fig. 2