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Table 1 Amyloigenic regions in Aβ24 and Aβ42 peptides predicted by the 11 indicated methods, and AMYLPRED2-derived consensus score

From: Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain

Method Aβ24 Aβ42
AGGRESCAN 17–22 17–22, 30–42
AmyloidMutants 4–12, 15–23 14–22, 34–42
Amyloidogenic Pattern 16–21 16–21
Average Packing Density 16–21 16–21, 32–37
Beta-strand contiguity 15–20 15–20, 29–41
Hexapeptide Conf. Energy 16–22 16–22, 29–42
NetCSSP 1–23 1–23, 28–37
Pafig 7–24 7–42
SecStr 15–20 15–20
TANGO 17–21 17–21, 29–41
WALTZ 15–24 15–23, 28–42
AMYLPRED2 (CONSENSUS5) 15–22 15–22, 29–42