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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

Fig. 1

Coronal sections of the cerebrum at the subthalamic nucleus. a Patient 7 with fused in sarcoma (FUS)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI) showed enlargement of the anterior horn of the lateral ventricle, and atrophy of the caudate nucleus, putamen, and frontal lobe, particularly in the frontal white matter along with a thin corpus callosum. However, the hippocampus and temporal lobe were preserved. b Patient 2 with phosphorylated TAR DNA-binding protein 43 (pTDP-43)-ir NCI showed temporal predominately frontotemporal atrophy. c Patient 4 with pTDP-43-ir NCI showed no white matter atrophy nor enlargement of the lateral ventricle. The globus pallidus and subthalamic nucleus were brownish with mild to severe atrophy, while the caudate nucleus and the putamen were relatively preserved in all patients except for patient 7 (a), and the optic nerve was preserved in all patients. (Bar = 2 cm)

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