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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

Fig. 8

Dictyostatin treatment caused a significant reduction of insoluble TauAcK280. a The high salt buffer-insoluble fraction from combined cortical and hippocampal homogenates of vehicle- and dictyostatin-treated aged PS19 mice were analyzed for the amount of TauAcK280 by immunoblotting. Samples from PS19 mice receiving vehicle (n = 9) or 0.1 mg/kg of dicytostatin (n = 8) were analyzed on two separate gels, with the densitometric values for TauAcK280 bands from the vehicle and dictyostatin samples (a) compared and normalized for each gel after immunoblotting. b A plot of the relative TauAcK280 values in the vehicle- and dictyostatin-treated PS19 mice. c A similar analysis was performed in which immunoblots were probed with the AT8 antibody that recognizes tau that is phosphorylated at Ser202/Thr205. Error bars denote SEM. *, p < 0.05 as determined by a two-tailed t-test

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Acta Neuropathologica Communications

ISSN: 2051-5960

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