Fig. 5

Dictyostatin treatment decreased axonal dystrophy in optic nerves of aged PS19 mice. a A representative electron micrograph showing an example of a dystrophic axon within the optic nerve from a study mouse (bar = 0.5 μm). b The number of dystrophic axons were counted in electron micrographs of cross-sections of optic nerves from dictyostatin- or vehicle-treated aged PS19 or WT mice, as previously described [46]. Error bars denote SEM, with group sizes of 8–11. *, p < 0.05; **, p < 0.01 as determined by one-way ANOVA with a post-hoc Tukey’s multiple comparison test