Fig. 2
From: Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
Expression of active caspase-8 correlates with the morphological transformation of Iba1-positive myeloid cells. Schematic overview of the distribution of myeloid cells in the 1) ischemic core 2) peri-infarct area and 3) surrounding area (a). Cell morphologies were divided into ramified, hypertrophic, amoeboid and rounded to reflect the states of activation. Examples of the different cell morphologies are given as cartoon and upon immunohistochemical staining for cleaved caspase-8 (b). Morphological quantifications of Iba1-positive cells (c) and cleaved caspase-8-positive cells (d) defined as cells per mm2 in the ischemic core (1), peri-infarct area (2) and surrounding area (3) in tissue from mice (n = 4) upon 48 h of pMCAO