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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy

Fig. 1

a Chronic cord compression was induced by surgical implantation of an expandable polymer underneath the posterior arches of C3/4. Sham surgery was conducted on controls (each experimental group n = 5). b Locomotor behaviour was assessed using open-field Basso Beattie Bresnahan (BBB). Spinal cord compression resulted in significant neurological deterioration within 1 week (****p < 0.0001). After 10 weeks, a laminectomy was performed and the implants removed. In the decompressed group, scores improved significantly three weeks after surgery (****p < 0.0001). Induction of SC compression also increased the number (c) forepaw and (d) hindpaw slips of rats placed on a grid as compared to controls. On the other hand, a significant reduction of forepaw and hindpaw slips was detected following surgical decompression (**p < 0.01, ****p < 0.0001)

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